Rewiring the Addicted Brain: Circuits-Based Treatment for Addiction
نویسندگان
چکیده
منابع مشابه
The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies.
Imaging studies have provided evidence of how the human brain changes as an individual becomes addicted. Here, we integrate the findings from imaging studies to propose a model of drug addiction. The process of addiction is initiated in part by the fast and high increases in DA induced by drugs of abuse. We hypothesize that this supraphysiological effect of drugs trigger a series of adaptations...
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Morphine is the most potent analgesic for chronic pain, but its clinical use has been limited by the opiate's innate tendency to produce tolerance, severe withdrawal symptoms and rewarding properties with a high risk of relapse. To understand the addictive properties of morphine, past studies have focused on relevant molecular and cellular changes in the brain, highlighting the functional roles...
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example is inflammation: perhaps the simplest form of pathology. It has well defined characteristics which, for many of the old continent, were described in latin: rubor, tumor, calor, dolor, and functio lesa. When these characteristics are present, the pathology/disease can be diagnosed. If it occurs in the lung it will indicate pneumonia, in the kidney nephritis etc. Likewise, a brain chronic...
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Balancing behaviors that provide a reward NOW versus behaviors that provide an advantage LATER is critical for survival. We propose a model in which dopamine (DA) can favor NOW processes through phasic signaling in reward circuits or LATER processes through tonic signaling in control circuits. At the same time, through its modulation of the orbitofrontal cortex, which processes salience attribu...
متن کاملThe addicted brain.
ERIC J. NESTLER and ROBERT C. MALENKA study the molecular basis of drug addiction. Nestler, professor in and chair of the department of psychiatry at the University of Texas Southwestern Medical Center at Dallas, was elected to the Institute of Medicine in 1998. Malenka, professor of psychiatry and behavioral sciences at the Stanford University School of Medicine, joined the faculty there after...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Symposia on Quantitative Biology
سال: 2018
ISSN: 0091-7451,1943-4456
DOI: 10.1101/sqb.2018.83.038158